Toxic Effect and Bioavailability of Malathion
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Date:
Wed, 18 Dec 2002
07:46:30 -0500
From:
Stephen Tvedten <steve@getipm.com>
Organization: Get Set Inc. (www.getipm.com)
To: Paul Helliker <phelliker@cdpr.ca.gov>
Director, State of California, Department of Pesticide
Regulation
cc: Christine Whitman whitman.christine@epa.gov
Toxic Effect and Bioavailability of Malathion Spiked in Natural Sediments from the Ignacio Ramirez Dam on the Snail Stagnicola sp
pp. 232-237 (doi:10.1006/eesa.2002.2162) Laura Martínez-Tabche1, M. Marcela Galar, H. Elena Olvera, R. Alejandro Chehue, Eugenia López López, Leobardo Gómez-Oliván, Oscar Terron Sierra
National School of Biological Sciences, National Polytechnic Institute, México, D.F., México
(Received June 18, 2001; published electronically September 16, 2002)
Abstract: Malathion (MA) is a widely used insecticide in México. The snail Stagnicola sp is a native species of the Ignacio Ramírez dam (IRD). This work aimed to evaluate the bioavailability and toxicity of MA in sediments of the IRD from the Stagnicola sp snail, taking into account the physicochemical properties of the IRD sediment. The toxic effect of MA on the snail Stagnicola sp was evaluated by biochemical tests of acetylcholinesterase (AchE) activity, protein concentration, lipid peroxidation level (LPL), and lipid content; a toxicokinetic study was also carried out. An increment in all biochemical parameters was observed at the beginning of exposure, while at 48 and 72 h a decrement in AchE activity, LPL, and lipid content was observed. The kinetics study showed gradual uptake and rapid elimination of the insecticide in the test organism. The bioconcentration factor and the absorption and elimination constants led to the conclusion that this compound is not being stored in snails. However, at the end of the experiment, the snails without MA exhibited a lack of recovery in AchE activity, which indicates that there is no correlation between the inhibitory pattern of AchE activity and snail MA concentration. © 2002 Elsevier Science (USA).
Key Words: malathion; acetylcholinesterase; lipid peroxidation; lipids; proteins; snails; bioconcentration factor; uptake; elimination.
To whom correspondence should be addressed. E-mail: Itabche@bios.encb.ipn.mx.
http://www.idealibrary.com/links/doi/10.1006/eesa.2002.2162
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